Endocrine Abstracts

The observed association between thyroid disorders and breast cancer has provoked many investigations. One area where there is some, although far from universal, agreement is the finding of an increased prevalence of anti-thyroid autoantibodies in breast cancer patients compared to controls. Whether this is a feature of a generalised autoimmune response to breast cancer, or provoked by the enzyme thyroid peroxidase acting as an autoantigen, remains unclear. In this study we lo...

Objective: To assess the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of sonographic index point and resistivity index in predicting the risk for malignancy in thyroid nodules.Methods: Fifty consecutive patients undergoing thyroid ultrasound for clinical nodular thyroid diseases prior to planned surgery were recruited for the study. Sonographic index point was calculated for each nodule using morphological...

Background: Previous studies reported that direct injection of estrogen (E2) into different hypothalamic nuclei affects food intake, body weight and locomotor activity. We hypothesized that E2 signaling in the hypothalamus regulates glucose metabolism independently of circulating estrogen levels.Methods: We investigated the effects of hypothalamic estrogen administration on basal glucose production as well as on hepatic and peripher...

Riedel thyroiditis is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. The etiological mechanism underlying RT are unclear. The prevailing view is that it is part of a generalized fibro-inflammatory process also involving other organs. Therapeutic options are not standardized (surgery, corticosteroids, and more recently tamoxifene). The aim of this work is to present three new cases, and the favourable evolution observed in one ...